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    Liver Cancer - Causes, Types, Symptoms & Treatment

    Today’s urban lifestyle and choices are the prime reasons behind the surging number of ailments. Millions of people adopting unhealthy habits encounter illness, disability and death. One of such ailments is liver cancer.

    Liver or hepatic cancer is one of the fastest spreading ailments in India. Every year around 50,000 Indians is diagnosed with this disease. 

    Keep reading to learn about the types, stages, symptoms, causes, treatment, and risk factors contributing to this cancer.

    Team Digit

    What Is Liver Cancer?

    When the cells in the liver grow at an abnormal speed leaving less space for new cells to develop, it results in the liver or hepatic cancer.

    What Causes Liver Cancer?

    Below is a list of reasons responsible for liver cancer.

    • Gender
    • Race or ethnicity
    • Heavy alcohol consumption
    • Excessive consumption of tobacco via cigarettes, gutkha etc.
    • Chronic viral hepatitis A and B
    • Inherited metabolic disease
    • Obesity
    • Type 2 diabetes etc.

    Signs and Symptoms of Liver Cancer

    The symptoms of hepatic cancer become primarily prominent in the later stages, including-

    Early Liver Cancer Symptoms

    • Unexplained weight loss
    • Vomiting
    • Nausea
    • Anorexia (loss of appetite)
    • Fatigue
    • Swelling in the abdomen (ascites)

    However, these symptoms are generic and can indicate other forms of cancer and chronic diseases as well.

    Stage 4 Liver Cancer Symptoms

    • Jaundice (yellowish discolouration of skin and sclera or the white part of the eye)
    • Abdominal pain
    • Pain near the right shoulder blade
    • Fluid build-up in the abdomen
    • Enlargement of liver or spleen or both
    • Back Pain
    • Itching
    • Fever
    • White-coloured stool

     

    Hepatic cancer may lead to swollen veins visible under our abdominal skin, bruising and bleeding. 

    In some cases, hepatic cancer initiates hormone production that affects other body organs and systems, including-

    • Gynaecomastia

    It is one of the liver cancer symptoms in males, causing breast enlargement or shrinkage of testicles.

    • Erythrocytosis 

    This increases the red blood cells level in the body.

    • High Cholesterol

    This is one of the primary risk factors for heart diseases.

    • Hypercalcemia

    When the calcium level increases, one may feel weak, nauseous, confused. This may also lead to constipation and muscle issues.

    • Hypoglycaemia

    Under this condition, an individual may feel fatigued as the blood sugar level deteriorates.

     

    However, there are no distinctive liver cancer symptoms in females.

    What Are the Risk Factors of Liver Cancer?

    Numerous risk factors make human bodies susceptible to developing liver cancer cells. Very Well Health published an article that states 40% of liver cancer is correlated with Hepatitis B and C, 11% with alcohol consumption, and 10% due to other problems. 

    What are those? Let us find out.

    • Cirrhosis
    • Non-Alcoholic Fatty Liver Diseases (NAFLD) 
    • Aflatoxins
    • Anabolic Steroid-Induced Liver Injury
    • Wilson Disease
    • Alpha-1 Antitrypsin Deficiency
    • Hemochromatosis
    • Glycogen Storage Disease
    • Primary Biliary Cholangitis
    • Porphyria Cutanea Tarda
    • Tyrosinemia

    The 4 Types of Liver Cancer

    For treatment purposes, oncologists have classified liver cancer into 4 categories -

    1. Transplantable Cancer

    This type includes Stage I and some Stage II cancers in the TNM system among patients without a history of cirrhosis or other ailments. If the patient’s body sustains surgery, this form of cancer can be removed entirely. Alternatively, doctors opt for liver transplants in such cases.

    2. Unresectable Cancer

    Though not spread to the lymph nodes or distant organs, this cancer variant develops at the junction of the liver and the major arteries, veins and bile ducts. Thus it cannot be removed safely through an operation.

    3. Inoperable Cancer With lOnly Local Disease

    Though this type is small and can be removed by surgery, the patient must be healthy enough to sustain surgery. Especially it is unsafe for patients with cirrhosis and other serious ailments.

    4. Advanced Cancer

    This variant includes Stage IVA and IVB in the TNM system. When the tumour spreads to lymph nodes or other organs, it is referred to as advanced or metastatic cancer.

    How Is Liver Cancer Diagnosed?

    Doctors conduct the following tests to diagnose liver cancer and its severity.

    • Blood tests
    • CT and MRI scan
    • Ultrasound
    • Biopsy

    Different Stages of Liver Cancer

     

    Oncologists have categorised different stages to determine the percentage and severity of liver cancer spread. Also, the staging process helps cancer specialists to evaluate the survival statistics of patients.

    Liver cancer stages range between I and IV. While Stage I refers to lesser spread, Stage IV indicates that the cancer cells have spread to a more significant portion.

    Go through the AJCC (American Joint Committee of Cancer) TNM Staging System to get a comprehensive idea.

     

    Liver Cancer Stages

     

    AJCC Stage

    Stage Grouping

    Description

    IA

    T1a

    A single tumour of 4/ 5 inch (2 cm) or smaller that is yet to grow into blood cells

    IA

    N0, M0

    Not spread to surrounding lymph nodes (N0) or distant parts (M0)

    IB

    T1b

    A single tumour larger than 4/5 inch (2 cm) yet to grown into blood vessels

    IB

    N0, M0

    Cancer cells not spread to surrounding lymph nodes or distant parts

    II

    T2

    A single tumour larger than 4 /5 inch (2 cm) grown into blood vessels, More than 1 tumour smaller than 2 inch (5 cm) across

    II

    N0, M0

    Not yet spread to surrounding lymph nodes (N0) or to distant areas (M0)

    IIIA

    T3

    More than one tumour of which one is larger than 2 inch (5 cm) across

    IIIA

    N0, M0

    Not yet spread to surround lymph nodes (N0) or to distant areas (M0)

    IIIB

    T4

    Minimum 1 tumour of any size grown into a primary branch of a large liver vein (portal or hepatic vein)

    IIIB

    N0, M0

    Yet to spread to surrounding lymph nodes (N0) or distant areas (M0)

    IVA

    Any T, N1, M0

    1 or multiple tumours of any size (NT) spread to surrounding lymph nodes (N1) but not at distant areas (M0)

    IVB

    Any T

    1 or multiple tumours of any size (Any T)

    IVB

    Any N

    May spread to surrounding lymph nodes (Any N)

    IVB

    M1

    Spread to distant organs like bones or lungs (M1)

    Here, T = size, number and spread of tumours 

    N = Surrounding lymph nodes

    M = Distant lymph nodes or organs like bones and lungs

    Nonetheless, there are more staging systems of liver cancer followed by doctors across the world. 

    Recommended Treatments for Liver Cancer

    Depending on the liver cancer stages, patients may consult different cancer specialists. The list includes-

    • Surgical oncologist (conduct surgeries)
    • Radiation oncologist (conducts radiation therapy)
    • Medical oncologist (treats cancers with medicines and suggest chemotherapy and immunotherapy, based on the condition)
    • Gastroenterologist (specialised in treating digestive system diseases)
    • Interventional radiologist (conducts ablations and embolisations)

    However, individuals suffering from stage 4 liver cancer may require additional assistance, including nurse practitioners, nurses, social workers, nutritionists, rehabilitation specialists, and other health professionals.

     

    Below is the list of the most-practised liver cancer treatments across the world.

    1. Surgery

    Two effective ways to cure liver cancer are surgical resection (removal of the tumour) and liver transplant. In this respect, the patients have to be healthy to survive the extensive surgery. 

     

    • Fragmentary Hepatectomy

    This process involves partial removal of the affected part. Surgeons recommend this treatment to patients with only 1 tumour that has not spread into blood vessels. 

    The process involves CT, or MRI scans with angiography to determine whether it is possible to remove the affected area. However, during surgeries, if the doctor finds that the tumour is too large to be removed, they do not conduct surgical resection.

    Risks and Side Effects

    Liver resection is a critical operation and thus conducted only by experts. If operated by an inexperienced oncologist, patients may suffer the following side effects-

    • Bleeding
    • Infection
    • Complications due to anaesthesia
    • Blood coagulation
    • Pneumonia and more

    If the affected area is not eradicated, it may lead to new carcinogenic cell development in the liver.

     

    • Liver Transplantation

    When the tumours are more in number and more prominent in size, oncologists opt for transplantation. 

    Note: Doctors recommend liver transplantation if the tumour is smaller than 5 cm or there are 2 or 3 tumours of less than 3 cm in size and not grown into the blood vessels. 

    Liver transplantation is an expensive surgery but assures no new cancer develops further.

    Risks and Side Effects

    Patients who need liver transplantation have to wait until finding a suitable donor. They have to undergo other treatments like embolisation and ablation to stop the spread further. Also, doctors suggest a surgical resection to control the spread and then transplant the liver when available.

    Similar to partial hepatectomy, liver transplantation involves several risks. Therefore, it should be treated by reliable surgeons only. Elsewise, one may suffer-

    • Bleeding
    • Infection
    • Blood coagulation and more

    However, before transplantation, several checks like blood tests, biopsies etc., are conducted to avoid rejection of the new liver.

    2. Chemotherapy

    Also known as chemo, this treatment destroys cancer cells with the use of drugs. Doctors recommend this therapy if a patient cannot survive surgery and does not respond to other therapies like ablation or embolisation.

    There are 3 types of chemotherapies widely practised by oncologists-

    • Systematic
    • Regional
    • Hepatic Artery

    Risks and Side Effects

    Some of the common side effects of chemotherapy include-

    • Hair loss
    • Mouth sores
    • Anorexia (loss of appetite)
    • Nausea
    • Diarrhoea
    • White and red blood cell count deterioration etc.

    These side effects last till the treatment. Individuals can seek assistance from experts to reduce them.

    3. Additional Liver Cancer Treatments

    Experts have come up with several forms of treatments for unresectable tumours. It includes-

    • Clinical trials of the latest targeted therapies 
    • Immunotherapy
    • Other forms of chemotherapies
    • Radiation therapy and more

    4. Stage 4 Liver Cancer Treatment

    If the tumour spreads to lymph nodes or other body organs, experts recommend the following treatments-

    • Medications
    • Clinical trials
    • External Beam Radiation Therapy (EBRT)
    • Stereotactic Body Radiation Therapy (SBRT)

    What Is the Prognosis of Liver Cancer?

    According to Cancer.Net, the 5-year liver cancer survival rate depends on a patient’s health condition and the stage of the ailment. For instance, 44% of patients diagnosed with hepatic cancer at the early stage has 34% 5-year survival rate. If cancer spread to surrounding parts or tissues or lymph nodes, the rate is 12%. And patients suffering from last stage liver cancer have a 5-year survival rate of 3% only.

    However, in 2020, about 4.7%, that is, 9,05,677 new liver cancer cases, were reported worldwide, and the death rate was 8.3%. So, if you come across any of the mentioned liver cancer symptoms, opt for a thorough check-up to get it diagnosed at the early stage to reduce the spread rate.

    Frequently Asked Questions

    How can I prevent myself from liver cancer?

    To prevent liver cancer, stop tobacco and alcohol consumption, maintain your weight, be sure to get Hepatitis B vaccination and try to maintain a healthy lifestyle.

    To prevent liver cancer, stop tobacco and alcohol consumption, maintain your weight, be sure to get Hepatitis B vaccination and try to maintain a healthy lifestyle.

    Does Primary Biliary Cirrhosis increase the risk of liver cancer?

    Primary Biliary Cirrhosis (PBC) causes inflammation and severely hampers bile ducts in the liver. Thus it increases the risk of liver cancer.

    Primary Biliary Cirrhosis (PBC) causes inflammation and severely hampers bile ducts in the liver. Thus it increases the risk of liver cancer.

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    Last updated: 08-05-2025

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    Go Digit General Insurance Limited | Corporate Office Address: Atlantis, 95, 4th B Cross Road, Koramangala Industrial Layout, 5th Block, Bengaluru 560095 | Registered Office Address: 1 to 6 floors, Ananta One (AR One), Pride Hotel Lane, Narveer Tanaji Wadi, Shivaji Nagar, Pune-411005, Maharashtra | Trade logo of Go Digit General Insurance Ltd. displayed above belongs to Go Digit lnfoworks Services Private Limited and is provided and used by Go Digit General Insurance Ltd. under license.

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